Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors.

Article

Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors.

Oncogene - 1 Nov 1994

Murty V V, Li R G, Houldsworth J, Bronson D L, Reuter V E, Bosl G J, Chaganti R S

Abstract excerpt

The DCC tumor suppressor gene has been shown to be frequently deleted or its expression reduced or absent in colorectal, gastro-intestinal, pancreatic, prostatic, and breast carcinomas, and glioblastomas. By allelotype analysis using the DCC-flanking polymorphic marker D18S5 we have previously sh...

Topics

Alleles
Chromosomes, Human, Pair 18
Gene Deletion
Gene Expression
Genes, DCC
Germinoma
Heterozygote
Homozygote
Humans
Male
Polymorphism, Restriction Fragment Length
Tumor Cells, Cultured

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