Article
Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors.
Oncogene - 1 Nov 1994
Murty V V, Li R G, Houldsworth J, Bronson D L, Reuter V E, Bosl G J, Chaganti R S
Abstract excerpt
The DCC tumor suppressor gene has been shown to be frequently deleted or its expression reduced or absent in colorectal, gastro-intestinal, pancreatic, prostatic, and breast carcinomas, and glioblastomas. By allelotype analysis using the DCC-flanking polymorphic marker D18S5 we have previously shown that allelic deletions at 18q21 occur in 40% of male germ cell tumors (Murty et al., 1994). In order to further...
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