Identifying genetic changes associated with tumor progression in squamous cell carcinoma.

doi:10.3109/00016489709124130

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Article

Identifying genetic changes associated with tumor progression in squamous cell carcinoma.

Acta oto-laryngologica. Supplementum - 1 Jan 1997

Carey T E, Frank C J, Raval J R, Jones J W, McClatchey K D, Beals T F, Worsham M J, Van Dyke D L

Abstract excerpt

Tumor behavior is the result of specific genetic changes that alter gene expression. From our cytogenetic studies chromosome 18 loss emerged as a common genetic change in squamous carcinoma cell lines. In this report we summarize data that link loss of 18 to tumor progression and reduced survival, indicating that one or more tumor suppressor gene(s) are located on this chromosome. Tumors grown in vitro were...

Topics

Carcinoma, Squamous Cell
Chromosomes, Human, Pair 18
DNA, Neoplasm
Genes, DCC
Genes, Tumor Suppressor
Heterozygote
Humans
Karyotyping
Microsatellite Repeats
Mutation
Tumor Cells, Cultured

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Identifiers

PMID: 9288318
DOI: 10.3109/00016489709124130

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