Article
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.
Nature genetics - 1 Jul 1996
Thiagalingam S, Lengauer C, Leach F S, Schutte M, Hahn S A, Overhauser J, Willson J K, Markowitz S, Hamilton S R, Kern S E, Kinzler K W, Vogelstein B
Abstract excerpt
Chromosome deletions are the most common genetic events observed in cancer. These deletions are generally thought to reflect the existence of a tumour suppressor gene within the lost region. However, when the lost region does not precisely coincide with a hereditary cancer locus, identification o...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Adhesion Molecules
- Chromosome Mapping
- Chromosomes, Human, Pair 18
- Colorectal Neoplasms
- DCC Receptor
- DNA Mutational Analysis
- DNA-Binding Proteins
- Genes, Tumor Suppressor
- Genetic Markers
- Humans
- In Situ Hybridization, Fluorescence