Article
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.
Nature genetics - 1 Jul 1996
Thiagalingam S, Lengauer C, Leach F S, Schutte M, Hahn S A, Overhauser J, Willson J K, Markowitz S, Hamilton S R, Kern S E, Kinzler K W, Vogelstein B
Abstract excerpt
Chromosome deletions are the most common genetic events observed in cancer. These deletions are generally thought to reflect the existence of a tumour suppressor gene within the lost region. However, when the lost region does not precisely coincide with a hereditary cancer locus, identification of the putative tumour suppressor gene (target of the deletion) can be problematic. For example, previous studies have...
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