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Article

Lower frequency of allele loss on chromosome 18q in human breast cancer than in colorectal tumors.

Journal of molecular medicine (Berlin, Germany) - 1 Mar 1996

Schenk M, Leib-Mösch C, Schenck I U, Jaenicke M, Indraccolo S, Saeger H D, Dallenbach-Hellweg G, Hehlmann R

Abstract excerpt

Inactivation of tumor suppressor genes is thought to be a critical step in tumorigenesis. The DCC (deleted in colorectal carcinoma) gene, located on the long arm of chromosome 18, has been shown to be frequently deleted in colorectal tumors. To investigate the involvement of allelic deletions on chromosome 18q in breast cancer tumorigenesis we analyzed 28 primary breast tumors and 28 colorectal tumors (24...

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Source

Identifiers

PMID: 8846166
DOI: 10.1007/BF01575448

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lower frequency of allele loss on chromosome 18q in human breast cancer than in colorectal tumors.PMID 8846166Read ↗

Mapping of a breast cancer tumor suppressor gene locus to a 4-cM interval on chromosome 18q21.Semantic proximity Read ↗

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.Semantic proximity Read ↗

Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.Semantic proximity Read ↗

Genetic alterations of microsatellites on chromosome 18 in human breast carcinoma.Semantic proximity Read ↗

Somatic genetic changes on chromosome 18 in breast carcinomas: is the DCC gene involved?Semantic proximity Read ↗

Identification of a chromosome 18q gene that is altered in colorectal cancers.Semantic proximity Read ↗

Allelic analysis of serous ovarian carcinoma reveals two putative tumor suppressor loci at 18q22-q23 distal to SMAD4, SMAD2, and DCC.Semantic proximity Read ↗

Chromosome allele loss in colorectal liver metastases and its association with clinical features.Semantic proximity Read ↗

Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors.Semantic proximity Read ↗

Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer.Semantic proximity Read ↗

Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers.Semantic proximity Read ↗

Loss of heterozygosity on chromosomes 17 and 18 in breast carcinoma: two additional regions identified.Semantic proximity Read ↗

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