Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).

doi:10.1371/journal.pone.0008037

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Article

Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).

PloS one - 7 Dec 2009

Hellquist Anna, Zucchelli Marco, Lindgren Cecilia M, Saarialho-Kere Ulpu, Järvinen Tiina M, Koskenmies Sari, Julkunen Heikki, Onkamo Päivi, Skoog Tiina, Panelius Jaana, Räisänen-Sokolowski Anne, Hasan Taina, Widen Elisabeth, Gunnarson Iva, Svenungsson Elisabet, Padyukov Leonid, Assadi Ghazaleh, Berglind Linda, Mäkelä Ville-Veikko, Kivinen Katja, Wong Andrew, Cunningham Graham Deborah S, Vyse Timothy J, D'Amato Mauro, Kere Juha

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with multiple susceptibility genes. We have previously reported suggestive linkage to the chromosomal region 14q21-q23 in Finnish SLE families. PRINCIPAL FINDINGS: Genetic fine mapping of this region in the same family material, together with a large collection of parent affected trios from UK and two independent case-control cohorts...

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Identifiers

PMID: 19997561
DOI: 10.1371/journal.pone.0008037
PMCID: PMC2785483

Genes

ITGAM
MDGA2
TNF

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