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Article

Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.

International journal of molecular sciences - 16 Jul 2021

Saeed Mohammad, Ibáñez-Costa Alejandro, Patiño-Trives Alejandra María, Muñoz-Barrera Laura, Collantes Estévez Eduardo, Aguirre María Ángeles, López-Pedrera Chary

Abstract excerpt

OBJECTIVES: This study employed genetic and functional analyses using OASIS meta-analysis of multiple existing GWAS and gene-expression datasets to identify novel SLE genes. METHODS: Four hundred and ten genes were mapped using SNIPPER to 30 SLE GWAS loci and investigated for expression in three SLE GEO-datasets and the Cordoba GSE50395-dataset. Blood eQTL for significant SNPs in SLE loci and STRING for...

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Identifiers

PMID: 34299244
DOI: 10.3390/ijms22147624
PMCID: PMC8304828

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