Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus.

doi:10.1073/pnas.0901181106

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Article

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus.

Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2009

Jacob Chaim O, Zhu Jiankun, Armstrong Don L, Yan Mei, Han Jie, Zhou Xin J, Thomas James A, Reiff Andreas, Myones Barry L, Ojwang Joshua O, Kaufman Kenneth M, Klein-Gitelman Marisa, McCurdy Deborah, Wagner-Weiner Linda, Silverman Earl, Ziegler Julie, Kelly Jennifer A, Merrill Joan T, Harley John B, Ramsey-Goldman Rosalind, Vila Luis M, Bae Sang-Cheol, Vyse Timothy J, Gilkeson Gary S, Gaffney Patrick M, Moser Kathy L, Langefeld Carl D, Zidovetzki Raphael, Mohan Chandra

Abstract excerpt

A combined forward and reverse genetic approach was undertaken to test the candidacy of IRAK1 (interleukin-1 receptor associated kinase-1) as an X chromosome-encoded risk factor for systemic lupus erythematosus (SLE). In studying approximately 5,000 subjects and healthy controls, 5 SNPs spanning the IRAK1 gene showed disease association (P values reaching 10(-10), odds ratio >1.5) in both adult- and...

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Identifiers

PMID: 19329491
DOI: 10.1073/pnas.0901181106
PMCID: PMC2669395

Genes

IRAK1

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