Article
Identification of Shared and Asian-Specific Loci for Systemic Lupus Erythematosus and Evidence for Roles of Type III Interferon Signaling and Lysosomal Function in the Disease: A Multi-Ancestral Genome-Wide Association Study.
Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2022
Wang Yong-Fei, Wei Wei, Tangtanatakul Pattarin, Zheng Lichuan, Lei Yao, Lin Zhiming, Qian Chengmin, Qin Xiao, Hou Fei, Zhang Xinyu, Shao Li, Satproedprai Nusara, Mahasirimongkol Surakameth, Pisitkun Prapaporn, Song Qin, Lau Yu Lung, Zhang Yan, Hirankarn Nattiya, Yang Wanling
Abstract excerpt
OBJECTIVE: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease with differences in prevalence and severity among ancestral groups. This study was undertaken to identify novel genetic components, either shared by or distinct between Asian and European populations. METHODS: Both trans-ancestral and ancestry-specific meta-analyses of genome-wide association studies (GWAS) for SLE were performed,...
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