Article
Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.
Annals of the rheumatic diseases - 1 Jun 2017
Terao Chikashi, Kawaguchi Takahisa, Dieude Philippe, Varga John, Kuwana Masataka, Hudson Marie, Kawaguchi Yasushi, Matucci-Cerinic Marco, Ohmura Koichiro, Riemekasten Gabriela, Kawasaki Aya, Airo Paolo, Horita Tetsuya, Oka Akira, Hachulla Eric, Yoshifuji Hajime, Caramaschi Paola, Hunzelmann Nicolas, Baron Murray, Atsumi Tatsuya, Hassoun Paul, Torii Takeshi, Takahashi Meiko, Tabara Yasuharu, Shimizu Masakazu, Tochimoto Akiko, Ayuzawa Naho, Yanagida Hidetoshi, Furukawa Hiroshi, Tohma Shigeto, Hasegawa Minoru, Fujimoto Manabu, Ishikawa Osamu, Yamamoto Toshiyuki, Goto Daisuke, Asano Yoshihide, Jinnin Masatoshi, Endo Hirahito, Takahashi Hiroki, Takehara Kazuhiko, Sato Shinichi, Ihn Hironobu, Raychaudhuri Soumya, Liao Katherine, Gregersen Peter, Tsuchiya Naoyuki, Riccieri Valeria, Melchers Inga, Valentini Gabriele, Cauvet Anne, Martinez Maria, Mimori Tsuneyo, Matsuda Fumihiko, Allanore Yannick
Abstract excerpt
OBJECTIVES: Systemic sclerosis (SSc) is an autoimmune disease characterised by skin and systemic fibrosis culminating in organ damage. Previous genetic studies including genome-wide association studies (GWAS) have identified 12 susceptibility loci satisfying genome-wide significance. Transethnic meta-analyses have successfully expanded the list of susceptibility genes and deepened biological insights for other...
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