The influence of type I collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization.

doi:10.1006/excr.1995.1005

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Article

The influence of type I collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: modification of expression of genes supporting cell growth, adhesion, and extracellular matrix mineralization.

Experimental cell research - 1 Jan 1995

Lynch M P, Stein J L, Stein G S, Lian J B

Abstract excerpt

Osteoblasts derived from Day 21 fetal rat calvaria grown on films of collagen type I exhibit an earlier and enhanced expression of the differentiated phenotype, compared to cells cultured on plastic. The temporal expression of genes characterizing three distinct periods of growth and differentiation are dramatically modified. During the initial proliferation period, expression of genes normally expressed at high...

Topics

Alkaline Phosphatase
Animals
Biomarkers
Calcification, Physiologic
Calcium-Binding Proteins
Cell Adhesion
Cell Differentiation
Cell Division
Cells, Cultured
Cholecalciferol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Collagen

Embryonic and Fetal Development

Extracellular Matrix Proteins

Gene Expression Regulation, Developmental

Osteoblasts

Osteopontin

Phenotype

Plastics

Source

Open in PubMed

Identifiers

PMID: 7813631
DOI: 10.1006/excr.1995.1005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7813631-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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