Article
Readaptation of a low-virulence influenza H9 escape mutant in mice: the role of changes in hemagglutinin as revealed by site-specific mutagenesis.
Archives of virology - 1 Jan 2010
Ilyushina N A, Rudneva I A, Khalenkov A M, Timofeeva T A, Krylov P S, Webster R G, Kaverin N V
Abstract excerpt
In our earlier studies, we showed that an escape mutant of mouse-adapted H9N2 influenza virus carrying a T198N amino acid change in heamagglutinin (HA) has a lowered virulence for mice. The readaptation of this mutant to mice was associated with N198S or N198D reverse mutations. In this study, single-gene reassortants having HA gene of the wild-type virus, its low-virulence escape mutant, or a readapted variant...
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