Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation.

PloS one - 1 Jan 2020

Choi Eun-Ji, Lee Young Jae, Lee Jin-Moo, Kim Yeon-Jung, Choi Jang-Hoon, Ahn Byeongwoo, Kim Kisoon, Han Myung Guk

Abstract excerpt

Elucidating the genetic basis of influenza A viruses (IAVs) is important to understand which mutations will determine the virulence and the host range of mammals. Here, seasonal H3N2 influenza was adapted in mice by serial passage and four mutants, each carrying amino acid substitutions related to mouse adaptation in either the PB2, HA, NP, or NA protein, were generated. To confirm the contribution of each gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host Microbial Interactions

Share to Influenza A Virus, H3N2 Subtype

Share to Reassortant Viruses

Share to Virulence

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 31917822
DOI: 10.1371/journal.pone.0227516
PMCID: PMC6952113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation.PMID 31917822Read ↗

Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus.Semantic proximity Read ↗

A PB1-K577E Mutation in H9N2 Influenza Virus Increases Polymerase Activity and Pathogenicity in MiceSemantic proximity Read ↗

Adaptation of Pandemic H1N1 Influenza Viruses in MiceSemantic proximity Read ↗

Adaptation of influenza A(H1N1)pdm09 virus in experimental mouse models.Semantic proximity Read ↗

Adaptive amino acid substitutions enhance the virulence of a novel human H7N9 influenza virus in mice.Semantic proximity Read ↗

Exploring the alternative virulence determinants PB2 S155N and PA S49Y/D347G that promote mammalian adaptation of the H9N2 avian influenza virus in miceSemantic proximity Read ↗

Multiple adaptive amino acid substitutions increase the virulence of a wild waterfowl-origin reassortant H5N8 avian influenza virus in mice.Semantic proximity Read ↗

Adaption of seasonal H1N1 influenza virus in mice.Semantic proximity Read ↗

Adaptation of human influenza H3N2 virus in a mouse pneumonitis model: insights into viral virulence, tissue tropism and host pathogenesis.Semantic proximity Read ↗

Mutations during the adaptation of H7N9 avian influenza virus to mice lungs enhance human-like sialic acid binding activity and virulence in mice.Semantic proximity Read ↗

Molecular basis of efficient replication and pathogenicity of H9N2 avian influenza viruses in mice.Semantic proximity Read ↗

Mouse-adapted H9N2 avian influenza virus causes systemic infection in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.