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A single-amino-acid mutation at position 225 in hemagglutinin attenuates H5N6 influenza virus in mice

1 Jan 2021

Abstract excerpt

The highly pathogenic avian influenza H5N6 viruses are widely circulating in poultry and wild birds, and have caused 38 human infections including 21 deaths; however, the key genetic determinants of the pathogenicity of these viruses have yet to be fully investigated. Here, we characterized two H5N6 avian influenza viruses – A/duck/Guangdong/S1330/2016 (GD/330) and A/environment/Fujian/S1160/2016 (FJ/160) – that...

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PMID: 34686117
DOI: 10.1080/22221751.2021.1997340

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