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Article

Adaption of seasonal H1N1 influenza virus in mice.

PloS one - 1 Jan 2011

Xu Lili, Bao Linlin, Li Fengdi, Lv Qi, Ma Yila, Zhou Jiangfang, Xu Yanfeng, Deng Wei, Zhan Lingjun, Zhu Hua, Ma Chunmei, Shu Yuelong, Qin Chuan

Abstract excerpt

The experimental infection of a mouse lung with influenza A virus has proven to be an invaluable model for studying the mechanisms of viral adaptation and virulence. The mouse adaption of human influenza A virus can result in mutations in the HA and other proteins, which is associated with increased virulence in mouse lungs. In this study, a mouse-adapted seasonal H1N1 virus was obtained through serial...

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Identifiers

PMID: 22194944
DOI: 10.1371/journal.pone.0028901
PMCID: PMC3241702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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