Article
Mouse-adapted H9N2 avian influenza virus causes systemic infection in mice.
Virology journal - 12 Nov 2019
Hu Zhe, Zhang Yiran, Wang Zhen, Wang Jingjing, Tong Qi, Wang Mingyang, Sun Honglei, Pu Juan, Liu Changqing, Liu Jinhua, Sun Yipeng
Abstract excerpt
BACKGROUND: H9N2 influenza viruses continuously circulate in multiple avian species and are repeatedly transmitted to humans, posing a significant threat to public health. To investigate the adaptation ability of H9N2 avian influenza viruses (AIVs) to mammals and the mutations related to the host switch events, we serially passaged in mice two H9N2 viruses of different HA lineages - A/Quail/Hong Kong/G1/97 (G1)...
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