Article
D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice.
Experimental biology and medicine (Maywood, N.J.) - 1 Aug 2010
Zheng Bojian, Chan Kwok-Hung, Zhang Anna J X, Zhou Jie, Chan Chris C S, Poon Vincent K M, Zhang Ke, Leung Virtual H C, Jin Dong-Yan, Woo Patrick C Y, Chan Jasper F W, To Kelvin K W, Chen Honglin, Yuen Kwok-Yung
Abstract excerpt
Although the majority of infections by the pandemic influenza H1N1 (2009) virus is mild, a higher mortality occurs in young adults with no risk factors for complications. Some of these severe cases were infected by the virus with an aspartate to glycine substitution at 225 position (D225G, H3 numbering) in the hemagglutinin (HA). Previous studies with the highly virulent 1918 pandemic H1N1 virus suggested that...
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