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Article

K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer.

International journal of colorectal disease - 1 Feb 2010

Schimanski Carl C, Zimmermann Tim, Schmidtmann Irene, Gockel Ines, Lang Hauke, Galle Peter R, Moehler Markus, Berger Martin R

Abstract excerpt

AIM: We initiated this study in order to analyze whether the expression level of targeted receptor tyrosine kinases (RTK) is associated with the K-ras mutation status. METHODS: The expression pattern of VEGFR1, VEGFR2, VEGFR3, PDGFRalpha, PDGFRbeta, and EGFR1 was analyzed in 93 samples of human colorectal carcinoma samples and correlated with the K-ras mutation status as identified by PCR-RFLP. RESULTS: VEGFR1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19936766
DOI: 10.1007/s00384-009-0843-7

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