Article
VEGF, VEGFR3, and PDGFRB protein expression is influenced by RAS mutations in medullary thyroid carcinoma.
Thyroid : official journal of the American Thyroid Association - 1 Aug 2014
Mancikova Veronika, Inglada-Pérez Lucía, Curras-Freixes Maria, de Cubas Aguirre A, Gómez Álvaro, Letón Rocío, Kersten Iris, Leandro-García Luis Javier, Comino-Méndez Iñaki, Apellaniz-Ruiz María, Sánchez Lara, Cascón Alberto, Sastre-Marcos Julia, García Juan F, Rodríguez-Antona Cristina, Robledo Mercedes
Abstract excerpt
BACKGROUND: Tyrosine kinase inhibitors (TKIs) have achieved remarkable clinical results in medullary thyroid carcinoma (MTC) patients. However, the considerable variability in patient response to treatment with TKIs remains largely unexplained. There is evidence that it could be due, at least in part, to alterations in genes associated with the disease via their effect on the expression of TKI targets. The...
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