Article
K-Ras gene mutation status as a prognostic and predictive factor in patients with colorectal cancer undergoing irinotecan- or oxaliplatin-based chemotherapy.
Cancer biology & therapy - 1 Nov 2012
Stec Rafał, Bodnar Lubomir, Charkiewicz Radosław, Korniluk Jan, Rokita Marta, Smoter Marta, Ciechowicz Marzena, Chyczewski Lech, Nikliński Jacek, Kozłowski Wojciech, Szczylik Cezary
Abstract excerpt
BACKGROUND: CRC caused more than 600,000 estimated deaths in 2008. Dysregulated signaling through the RAS/RAF/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway due to mutations in K-Ras and B-Raf are common events in CRC. METHODS: Incidence of mutations in codons 12 and 13 of K-Ras and exons 11 and 15 of B-Raf were analyzed in amplified PCR products from primary...
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