Article
Pattern of clinically relevant mutations in consecutive series of Russian colorectal cancer patients.
Medical oncology (Northwood, London, England) - 1 Jan 2013
Yanus Grigoriy A, Belyaeva Anna V, Ivantsov Alexandr O, Kuligina Ekatherina Sh, Suspitsin Evgeny N, Mitiushkina Natalia V, Aleksakhina Svetlana N, Iyevleva Aglaya G, Zaitseva Olga A, Yatsuk Olga S, Gorodnova Tatiana V, Strelkova Tatiana N, Efremova Sofia A, Lepenchuk Alla Yu, Ochir-Garyaev Altn N, Paneyah Moisey B, Matsko Dmitriy E, Togo Alexandr V, Imyanitov Evgeny N
Abstract excerpt
One hundred and ninety-five consecutive surgically treated Russian colorectal cancer (CRC) patients were retrospectively analyzed for the presence of mutations in KRAS, NRAS, BRAF and PIK3CA genes as well as for the microsatellite instability status. Comparison between high-resolution melting analysis, co-amplification at lower denaturation temperature PCR, DNA sequencing and allele-specific PCR for the detection...
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