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Article

PDGFRalpha gene mutation and protein expression in gastrointestinal stromal tumors.

Oncology - 1 Jan 2008

Chang Heung Moon, Ryu Min-Hee, Lee Hyoungnam, Jang Se Jin, Lee Jae-Lyun, Kim Tae Won, Yook Jeong Hwan, Oh Sung Tae, Kim Byung Sik, Lee Jung Shin, Kang Yoon-Koo

Abstract excerpt

OBJECTIVE: Mutation of the PDGFRalpha is a potential candidate in the pathogenesis of KIT wild-type gastrointestinal tumors (GISTs). In this study, we evaluated the prevalence of PDGFRalpha mutations and corresponding protein expression in GISTs, to determine their usefulness in obtaining a prognosis. METHODS: Genomic DNA was extracted from paraffin-embedded tumor tissues from 194 GISTs. Exons 12, 14 and 18 of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18547963
DOI: 10.1159/000139136

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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