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Article

PDGFRα/β and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome.

BMC cancer - 12 Nov 2012

Estevez-Garcia Purificacion, Castaño Angel, Martin Ana C, Lopez-Rios Fernando, Iglesias Joaquin, Muñoz-Galván Sandra, Lopez-Calderero Iker, Molina-Pinelo Sonia, Pastor Maria D, Carnero Amancio, Paz-Ares Luis, Garcia-Carbonero Rocio

Abstract excerpt

BACKGROUND: Angiogenesis plays an essential role in tumor growth and metastasis, and is a major target in cancer therapy. VEGFR and PDGFR are key players involved in this process. The purpose of this study was to assess the incidence of genetic variants in these receptors and its potential clinical implications in colorectal cancer (CRC). METHODS: VEGFR2, PDGFRα and PDGFRβ mutations were evaluated by sequencing...

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Identifiers

PMID: 23146028
DOI: 10.1186/1471-2407-12-514
PMCID: PMC3531259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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