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Article

Amplification of genes encoding KIT, PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme.

The Journal of pathology - 1 Oct 2005

Joensuu Heikki, Puputti Marjut, Sihto Harri, Tynninen Olli, Nupponen Nina N

Abstract excerpt

KIT, platelet-derived growth factor receptors (PDGFRs) and vascular endothelial growth factor receptors (VEGFRs) are important clinical targets for tyrosine kinase inhibitors. The frequency of KIT and VEGFR2 amplification in glioblastomas is not known, and few data are available in any other human tumour type. We investigated 43 primary glioblastomas for KIT, VEGFR2, PDGFRA and EGFR amplification using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Platelet-Derived Growth Factor alpha

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Source

Identifiers

PMID: 16021678
DOI: 10.1002/path.1823

Genes

KIT
EGFR
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Amplification of genes encoding KIT, PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme.PMID 16021678Read ↗

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Prevalence, clinico-pathological value, and co-occurrence of PDGFRA abnormalities in diffuse gliomas.Semantic proximity Read ↗

Molecular characterization of PDGFR-alpha/PDGF-A and c-KIT/SCF in gliosarcomas.Semantic proximity Read ↗

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The KDR (VEGFR-2) Genetic Polymorphism Q472H and c-KIT Polymorphism M541L Are Associated With More Aggressive Behaviour in Astrocytic Gliomas.Semantic proximity Read ↗

Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas.Semantic proximity Read ↗

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