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Article

Epidermal growth factor receptor (EGFR) status and K-Ras mutations in colorectal cancer.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Dec 2008

Milano G, Etienne-Grimaldi M-C, Dahan L, Francoual M, Spano J-P, Benchimol D, Chazal M, Letoublon C, André T, Gilly F-N, Delpero J-R, Formento J-L

Abstract excerpt

BACKGROUND: In advanced colorectal cancer, K-Ras somatic mutations predict resistance to mAbs targeting epidermal growth factor receptor (EGFR). Relationships between K-Ras mutations and EGFR status have not been examined so far. We analyzed relationships between K-Ras mutations and EGFR tumoral status based on EGFR germinal polymorphisms, gene copy number and expression. METHODS: Eighty colorectal tumors (stage...

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Identifiers

PMID: 18632722
DOI: 10.1093/annonc/mdn416
PMCID: PMC2733107

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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