Article
Use of high throughput sequencing to observe genome dynamics at a single cell level.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2009
Parkhomchuk D, Amstislavskiy V, Soldatov A, Ogryzko V
Abstract excerpt
With the development of high throughput sequencing technology, it becomes possible to directly analyze mutation distribution in a genome-wide fashion, dissociating mutation rate measurements from the traditional underlying assumptions. Here, we sequenced several genomes of Escherichia coli from colonies obtained after chemical mutagenesis and observed a strikingly nonrandom distribution of the induced mutations....
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