Article
Evolutionary dynamics and structural consequences of de novo beneficial mutations and mutant lineages arising in a constant environment.
BMC biology - 4 Feb 2021
Kinnersley Margie, Schwartz Katja, Yang Dong-Dong, Sherlock Gavin, Rosenzweig Frank
Abstract excerpt
BACKGROUND: Microbial evolution experiments can be used to study the tempo and dynamics of evolutionary change in asexual populations, founded from single clones and growing into large populations with multiple clonal lineages. High-throughput sequencing can be used to catalog de novo mutations as potential targets of selection, determine in which lineages they arise, and track the fates of those lineages. Here,...
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