Article
In vivo generation of DNA sequence diversity for cellular barcoding.
Nucleic acids research - 1 Jan 2014
Peikon Ian D, Gizatullina Diana I, Zador Anthony M
Abstract excerpt
Heterogeneity is a ubiquitous feature of biological systems. A complete understanding of such systems requires a method for uniquely identifying and tracking individual components and their interactions with each other. We have developed a novel method of uniquely tagging individual cells in vivo with a genetic 'barcode' that can be recovered by DNA sequencing. Our method is a two-component system comprised of a...
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