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Article

Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis.

PLoS genetics - 1 Nov 2009

Reischauer Sven, Levesque Mitchell P, Nüsslein-Volhard Christiane, Sonawane Mahendra

Abstract excerpt

Changes in tissue homeostasis, acquisition of invasive cell characteristics, and tumor formation can often be linked to the loss of epithelial cell polarity. In carcinogenesis, the grade of neoplasia correlates with impaired cell polarity. In Drosophila, lethal giant larvae (lgl), discs large (dlg), and scribble, which are components of the epithelial apico-basal cell polarity machinery, act as tumor suppressors,...

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Share to Cell Shape
Share to Epidermis
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19911055
DOI: 10.1371/journal.pgen.1000720
PMCID: PMC2771016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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