Article
Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis.
Cancer cell - 15 Nov 2011
Darido Charbel, Georgy Smitha R, Wilanowski Tomasz, Dworkin Sebastian, Auden Alana, Zhao Quan, Rank Gerhard, Srivastava Seema, Finlay Moira J, Papenfuss Anthony T, Pandolfi Pier Paolo, Pearson Richard B, Jane Stephen M
Abstract excerpt
Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains poorly understood. Here, we identify the developmental transcription factor Grhl3 as a potent tumor suppressor of SCC in mice, and demonstrate that targeting of Grhl3 by a miR-21-dependent proto-oncogenic network underpins SCC in humans. Deletion of Grhl3 in adult epidermis evokes loss of expression of PTEN, a direct GRHL3...
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