Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes.

Journal of cell science - 1 Mar 2007

Brennan Donna, Hu Ying, Joubeh Sohaila, Choi Yoo Won, Whitaker-Menezes Diana, O'Brien Thomas, Uitto Jouni, Rodeck Ulrich, Mahoney My G

Abstract excerpt

Desmoglein 2 (Dsg2), a component of the desmosomal cell-cell adhesion structure, has been linked to invasion and metastasis in squamous cell carcinomas. However, it is unknown whether--and if so how--Dsg2 contributes to the malignant phenotype of keratinocytes. In this study, we addressed the consequences of Dsg2 overexpression under control of the involucrin promoter (Inv-Dsg2) in the epidermis of transgenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Desmoglein 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermis

Share to Immunoblotting

Share to Keratinocytes

Share to Keratosis

Share to Microscopy, Electron, Transmission

Share to Protein Precursors

Source

Identifiers

PMID: 17284515
DOI: 10.1242/jcs.03392

Genes

EGF
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes.PMID 17284515Read ↗

Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal DifferentiationSemantic proximity Read ↗

Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis.Semantic proximity Read ↗

Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseasesSemantic proximity Read ↗

DSG2-Directed CAR-T Cells Safely and Universally Eliminate Solid TumorsSemantic proximity Read ↗

Basal cell carcinomas in mice overexpressing Gli2 in skin.Semantic proximity Read ↗

The p53-S100A2 Positive Feedback Loop Negatively Regulates Epithelialization in Cutaneous Wound HealingSemantic proximity Read ↗

PAD2 Overexpression in Transgenic Mice Promotes Spontaneous Skin NeoplasiaSemantic proximity Read ↗

Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling.Semantic proximity Read ↗

Skin fragility and impaired desmosomal adhesion in mice lacking all keratins.Semantic proximity Read ↗

Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis.Semantic proximity Read ↗

p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.Semantic proximity Read ↗

Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.