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Article

Corticosteroid receptor-gene variants: modulators of the stress-response and implications for mental health.

European journal of pharmacology - 13 May 2008

Derijk Roel H, van Leeuwen Nienke, Klok Melanie D, Zitman Frans G

Abstract excerpt

The stress-response, including autonomic and hypothalamic-pituitary-adrenal (HPA) axis reactivity, is essential for maintaining homeostasis during a challenge. Brain mineralocorticoid receptors and glucocorticoid receptors operate in balance to coordinate the stress-response. Genetic variants in both the human mineralocorticoid and glucocorticoid receptor-genes have been functionally characterized. In vitro...

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Share to Genetic Variation
Share to Hypothalamo-Hypophyseal System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptors, Mineralocorticoid

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Source

Identifiers

PMID: 18423443
DOI: 10.1016/j.ejphar.2008.03.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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