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Article

Genotoxic effects of neutrophils and hypochlorous acid.

Mutagenesis - 1 Mar 2010

Güngör Nejla, Knaapen Ad M, Munnia Armelle, Peluso Marco, Haenen Guido R, Chiu Roland K, Godschalk Roger W L, van Schooten Frederik J

Abstract excerpt

Chronic inflammation has been recognized as a contributing factor in the pathogenesis of lung cancer. In this process, reactive oxygen species released by neutrophils may play an important role. The aim of the present study was to investigate the capacity of the major neutrophilic oxidant hypochlorous acid (HOCl), which is formed by myeloperoxidase (MPO), to induce DNA damage and mutagenicity in lung cells. HOCl...

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Identifiers

PMID: 19892774
DOI: 10.1093/mutage/gep053

Genes

MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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