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Article

Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population.

International journal of cancer - 20 Nov 2002

Lu Wenfu, Xing Deyin, Qi Jun, Tan Wen, Miao Xiaoping, Lin Dongxin

Abstract excerpt

Myeloperoxidase (MPO), an enzyme derived from neutrophils, metabolically activates a wide range of carcinogens, whereas glutathione S-transferase M1 (GSTM1) detoxifies various electrophilic metabolites. A -463G-->A polymorphism in the promoter region of the MPO gene diminishes the expression of MPO and has been consistently shown to be associated with reduced risk of lung cancer in different ethnic populations....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12397651
DOI: 10.1002/ijc.10712

Genes

MPO
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population.PMID 12397651Read ↗

Myeloperoxidase G463A polymorphism and risk of lung cancer.Semantic proximity Read ↗

Myeloperoxidase -463G>A polymorphism and risk of primary lung cancer in a Korean population.Semantic proximity Read ↗

Myeloperoxidase -463 G/A polymorphism is associated with lung cancer risk: A meta-analysis with 7420 cases and 9132 controls.Semantic proximity Read ↗

[Lung cancer risk associated with genetic polymorphism in myeloperoxidase (-463 G/A) in a Chinese population].Semantic proximity Read ↗

The MPO-463G>A polymorphism and lung cancer risk: a meta-analysis based on 22 case-control studies.Semantic proximity Read ↗

Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers.Semantic proximity Read ↗

Association between MPO 463G>A polymorphism and risk of lung cancer: a meta-analysis.Semantic proximity Read ↗

Association between myeloperoxidase G-463A polymorphism and lung cancer risk.Semantic proximity Read ↗

Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk.Semantic proximity Read ↗

Myeloperoxidase: new polymorphisms and relation with lung cancer risk.Semantic proximity Read ↗

Myeloperoxidase G463A polymorphism and lung cancer risk in Asians: a pooled analysis.Semantic proximity Read ↗

CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.Semantic proximity Read ↗

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