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Article

Substantially reduced risk of cancer of the aerodigestive tract in subjects with variant--463A of the myeloperoxidase gene.

Cancer research - 1 Feb 2000

Cascorbi I, Henning S, Brockmöller J, Gephart J, Meisel C, Müller J M, Loddenkemper R, Roots I

Abstract excerpt

Myeloperoxidase (MPO), an enzyme that is highly expressed in neutrophil leukocytes, transforms precarcinogens such as benzo(a)pyrene and aromatic amines to highly reactive intermediates. A G/A polymorphism located 463 bp upstream of exon 1 in the promoter region strongly reduces MPO mRNA expression. In a matched case-control study, 196 lung cancer, 245 laryngeal cancer, and 255 pharyngeal cancer patients from the...

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Source

Identifiers

PMID: 10676648

Genes

MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Substantially reduced risk of cancer of the aerodigestive tract in subjects with variant--463A of the myeloperoxidase gene.PMID 10676648Read ↗

Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians.Semantic proximity Read ↗

Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk.Semantic proximity Read ↗

Myeloperoxidase -463 (G-->A) polymorphism associated with lower risk of lung cancer.Semantic proximity Read ↗

Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers.Semantic proximity Read ↗

Myeloperoxidase -463G>A polymorphism and risk of primary lung cancer in a Korean population.Semantic proximity Read ↗

Myeloperoxidase: new polymorphisms and relation with lung cancer risk.Semantic proximity Read ↗

Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis.Semantic proximity Read ↗

A myeloperoxidase polymorphism associated with reduced risk of lung cancer.Semantic proximity Read ↗

Myeloperoxidase G463A polymorphism and risk of lung cancer.Semantic proximity Read ↗

MyeloperoxidaseSemantic proximity Read ↗

Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population.Semantic proximity Read ↗

Association between myeloperoxidase G-463A polymorphism and lung cancer risk.Semantic proximity Read ↗

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