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Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2002

Feyler Anne, Voho Anu, Bouchardy Christine, Kuokkanen Katja, Dayer Pierre, Hirvonen Ari, Benhamou Simone

Abstract excerpt

Myeloperoxidase (MPO) is released from neutrophils in lung tissue in response to exposure to various pulmonary insults, including tobacco smoking. This enzyme is involved in the activation of an intermediate metabolite of benzo(a)pyrene to the highly reactive benzo(a)pyrene diol epoxide. A (-463)G --> A polymorphism in the promoter region of the MPO gene has been identified. The A allele is associated with a...

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PMID: 12496042

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MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Point: myeloperoxidase -463G --> a polymorphism and lung cancer risk.PMID 12496042Read ↗

Counterpoint: the myeloperoxidase -463G-->a polymorphism does not decrease lung cancer susceptibility in Caucasians.Semantic proximity Read ↗

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Myeloperoxidase G463A polymorphism and risk of lung cancer.Semantic proximity Read ↗

The MPO-463G>A polymorphism and lung cancer risk: a meta-analysis based on 22 case-control studies.Semantic proximity Read ↗

Myeloperoxidase: new polymorphisms and relation with lung cancer risk.Semantic proximity Read ↗

Association between myeloperoxidase G-463A polymorphism and lung cancer risk.Semantic proximity Read ↗

Myeloperoxidase -463G>A polymorphism and risk of primary lung cancer in a Korean population.Semantic proximity Read ↗

Myeloperoxidase -463 (G-->A) polymorphism associated with lower risk of lung cancer.Semantic proximity Read ↗

A myeloperoxidase polymorphism associated with reduced risk of lung cancer.Semantic proximity Read ↗

Myeloperoxidase G-463A polymorphism and lung cancer: a HuGE genetic susceptibility to environmental carcinogens pooled analysis.Semantic proximity Read ↗

Association between MPO 463G>A polymorphism and risk of lung cancer: a meta-analysis.Semantic proximity Read ↗

Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers.Semantic proximity Read ↗

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