Article
Cigarette smoke-induced damage-associated molecular pattern release from necrotic neutrophils triggers proinflammatory mediator release.
American journal of respiratory cell and molecular biology - 1 May 2015
Heijink Irene H, Pouwels Simon D, Leijendekker Carin, de Bruin Harold G, Zijlstra G Jan, van der Vaart Hester, ten Hacken Nick H T, van Oosterhout Antoon J M, Nawijn Martijn C, van der Toorn Marco
Abstract excerpt
Cigarette smoking, the major causative factor for the development of chronic obstructive pulmonary disease, is associated with neutrophilic airway inflammation. Cigarette smoke (CS) exposure can induce a switch from apoptotic to necrotic cell death in airway epithelium. Therefore, we hypothesized that CS promotes neutrophil necrosis with subsequent release of damage-associated molecular patterns (DAMPs),...
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