Article
Myeloperoxidase G-463A polymorphism and risk of lung and prostate cancer in a Turkish population.
Molecular medicine reports - 1 Jan 2000
Arslan Serdal, Pinarbasi Hatice, Silig Yavuz
Abstract excerpt
Myeloperoxidase (MPO) is a phase I enzyme that can bioactivate many specific procarcinogens, including polycyclic aromatic hydrocarbons and aromatic amines. The MPO gene contains a common single nucleotide polymorphism, for which the -463G>A substitution within the promoter region has been shown to reduce MPO expression and activity. We investigated the association between the MPO -463G>A polymorphism and lung...
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