Article
A myeloperoxidase polymorphism associated with reduced risk of lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Jul 2002
Schabath Matthew B, Spitz Margaret R, Hong Waun K, Delclos George L, Reynolds Wanda F, Gunn Gary B, Whitehead Lawrence W, Wu Xifeng
Abstract excerpt
Myeloperoxidase (MPO) is a metabolic/oxidative enzyme found in neutrophils and monocytes that contributes to pulmonary carcinogenesis through activation of specific procarcinogens including benzo[a]pyrene intermediates, 4-aminobiphenyl and the arylamines. There is a G-->A polymorphism located in the 5' untranslated region of the MPO gene that may be responsible for reduced transcriptional activity due to the...
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