Article
Ceramide kinase regulates phospholipase C and phosphatidylinositol 4, 5, bisphosphate in phototransduction.
Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2009
Dasgupta Ujjaini, Bamba Takeshi, Chiantia Salvatore, Karim Pusha, Tayoun Ahmad N Abou, Yonamine Ikuko, Rawat Satinder S, Rao Raghavendra Pralhada, Nagashima Kunio, Fukusaki Eiichiro, Puri Vishwajeet, Dolph Patrick J, Schwille Petra, Acharya Jairaj K, Acharya Usha
Abstract excerpt
Phosphoinositide-specific phospholipase C (PLC) is a central effector for many biological responses regulated by G-protein-coupled receptors including Drosophila phototransduction where light sensitive channels are activated downstream of NORPA, a PLCbeta homolog. Here we show that the sphingolipid biosynthetic enzyme, ceramide kinase, is a novel regulator of PLC signaling and photoreceptor homeostasis. A...
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