Article
Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants.
Scientific reports - 7 Dec 2015
Hebbar Sarita, Sahoo Ishtapran, Matysik Artur, Argudo Garcia Irene, Osborne Kathleen Amy, Papan Cyrus, Torta Federico, Narayanaswamy Pradeep, Fun Xiu Hui, Wenk Markus R, Shevchenko Andrej, Schwudke Dominik, Kraut Rachel
Abstract excerpt
Sphingolipid metabolites are involved in the regulation of autophagy, a degradative recycling process that is required to prevent neuronal degeneration. Drosophila blue cheese mutants neurodegenerate due to perturbations in autophagic flux, and consequent accumulation of ubiquitinated aggregates. Here, we demonstrate that blue cheese mutant brains exhibit an elevation in total ceramide levels; surprisingly,...
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