Regulation of PLC-mediated signalling in vivo by CDP-diacylglycerol synthase.

doi:10.1038/373216a0

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Article

Regulation of PLC-mediated signalling in vivo by CDP-diacylglycerol synthase.

Nature - 19 Jan 1995

Wu L, Niemeyer B, Colley N, Socolich M, Zuker C S

Abstract excerpt

CDP-diacylglycerol synthase (CDS) is an enzyme required for the regeneration of the signalling molecule phosphatidylinositol-4,5-bisphosphate (PtdlnsP2) from phosphatidic acid. A photo-receptor cell-specific isoform of CDS from Drosophila is a key regulator of phototransduction, a G-protein-coupled signalling cascade mediated by phospholipase C. cds mutants cannot sustain a light-activated current as a result of...

Topics

Amino Acid Sequence
Animals
CDPdiacylglycerol-Serine O-Phosphatidyltransferase
Drosophila
GTP-Binding Proteins
In Vitro Techniques
Light
Molecular Sequence Data
Mutation
Nerve Degeneration
Phosphatidic Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphatidylinositol 4,5-Diphosphate

Phosphatidylinositol Diacylglycerol-Lyase

Phosphatidylinositol Phosphates

Phosphoric Diester Hydrolases

Photoreceptor Cells, Invertebrate

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 7816135
DOI: 10.1038/373216a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7816135-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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