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Article

Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration.

Science (New York, N.Y.) - 14 Mar 2003

Acharya Usha, Patel Shetal, Koundakjian Edmund, Nagashima Kunio, Han Xianlin, Acharya Jairaj K

Abstract excerpt

Mutations in proteins of the Drosophila phototransduction cascade, a prototypic guanine nucleotide-binding protein-coupled receptor signaling system, lead to retinal degeneration and have been used as models to understand human degenerative disorders. Here, modulating the sphingolipid biosynthetic pathway rescued retinal degeneration in Drosophila mutants. Targeted expression of Drosophila neutral ceramidase...

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Identifiers

PMID: 12637747
DOI: 10.1126/science.1080549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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