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Article

Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid.

The Journal of cell biology - 9 May 2005

LaLonde Mary M, Janssens Hilde, Rosenbaum Erica, Choi Seok-Yong, Gergen J Peter, Colley Nansi J, Stark William S, Frohman Michael A

Abstract excerpt

Drosophila melanogaster phototransduction proceeds via a phospholipase C (PLC)-triggered cascade of phosphatidylinositol (PI) lipid modifications, many steps of which remain undefined. We describe the involvement of the lipid phosphatidic acid and the enzyme that generates it, phospholipase D (Pld), in this process. Pld(null) flies exhibit decreased light sensitivity as well as a heightened susceptibility to...

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Share to Phosphatidic Acids
Share to Phosphatidylinositol 4,5-Diphosphate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phospholipase D

Share to Phospholipid Transfer Proteins

Share to Photoreceptor Cells, Invertebrate

Share to Rhodopsin

Share to Type C Phospholipases

Share to Vision, Ocular

Source

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Identifiers

PMID: 15883198
DOI: 10.1083/jcb.200502122
PMCID: PMC2171926

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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