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Article

Ceramide transfer protein regulates G-protein-coupled phospholipase signalling in photoreceptors.

The Journal of cell biology - 5 Oct 2026

Mishra Shirish, Khan Ali, Nath Vaisaly R, Manoj Tejaswini, Balavali Gangadhar Thejaswini, Alex Preethi, Naik Amruta, Dasgupta Ujjaini, Raghu Padinjat

Abstract excerpt

Non-vesicular lipid transfer at membrane contact sites (MCS) is proposed as a key principle in eukaryotic cells. While several lipid transfer proteins (LTPs) are localized at MCS, their physiological significance is poorly understood. Ceramide transfer protein (CERT) transfers ceramide between membranes in vitro. However, evidence for the in vivo significance of CERT function is limited. We find that loss of...

Read the complete abstract on PubMed

Topics

Animals
Signal Transduction
Drosophila Proteins
Type C Phospholipases
Ceramides
Photoreceptor Cells, Invertebrate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Drosophila melanogaster

Phosphatidylinositol 4,5-Diphosphate

Carrier Proteins

Mutation

Cell Membrane

Endoplasmic Reticulum

Source

Identifiers

PMID: 42678424
DOI: 10.1083/jcb.202511193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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