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Article

Cell-nonautonomous function of ceramidase in photoreceptor homeostasis.

Neuron - 10 Jan 2008

Acharya Jairaj K, Dasgupta Ujjaini, Rawat Satinder S, Yuan Changqing, Sanxaridis Parthena D, Yonamine Ikuko, Karim Pusha, Nagashima Kunio, Brodsky Michael H, Tsunoda Susan, Acharya Usha

Abstract excerpt

Neutral ceramidase, a key enzyme of sphingolipid metabolism, hydrolyzes ceramide to sphingosine. These sphingolipids are critical structural components of cell membranes and act as second messengers in diverse signal transduction cascades. Here, we have isolated and characterized functional null mutants of Drosophila ceramidase. We show that secreted ceramidase functions in a cell-nonautonomous manner to maintain...

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Identifiers

PMID: 18184565
DOI: 10.1016/j.neuron.2007.10.041
PMCID: PMC2271043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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