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Article

Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants.

Proceedings of the National Academy of Sciences of the United States of America - 18 Sept 2018

Kunduri Govind, Turner-Evans Daniel, Konya Yutaka, Izumi Yoshihiro, Nagashima Kunio, Lockett Stephen, Holthuis Joost, Bamba Takeshi, Acharya Usha, Acharya Jairaj K

Abstract excerpt

Seizures induced by visual stimulation (photosensitive epilepsy; PSE) represent a common type of epilepsy in humans, but the molecular mechanisms and genetic drivers underlying PSE remain unknown, and no good genetic animal models have been identified as yet. Here, we show an animal model of PSE, in Drosophila, owing to defective cortex glia. The cortex glial membranes are severely compromised in ceramide...

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Identifiers

PMID: 30185559
DOI: 10.1073/pnas.1808463115
PMCID: PMC6156639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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