Article

Differential and compensatory roles for type I phosphatidylinositol-4-phosphate-5-kinase isoforms in retinal function and health

2026-05-26

Abstract excerpt

Phosphatidylinositol (4,5) bisphosphate (PI(4,5)P 2 ) plays important roles in development, signaling, intracellular trafficking and regulation throughout the nervous system. Using selective and combined gene ablation strategies, we have determined the roles of this lipid and the kinase isoforms of the PIP5KI family primarily responsible for its synthesis in mouse retina. In rod cells, PI(4,5)P 2 localizes predo...

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Literature Corpus work: 47c598d0-e65e-5d44-8995-74f8430ced26
DOI: 10.64898/2026.05.21.726920

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