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Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.

The Journal of biological chemistry - 27 Jan 2006

Henry L Keith, Field Julie R, Adkins Erika M, Parnas M Laura, Vaughan Roxanne A, Zou Mu-Fa, Newman Amy H, Blakely Randy D

Abstract excerpt

In previous studies examining the structural determinants of antidepressant and substrate recognition by serotonin transporters (SERTs), we identified Tyr-95 in transmembrane segment 1 (TM1) of human SERT as a major determinant of binding for several antagonists, including racemic citalopram ((RS...

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PMID: 16272152
DOI: 10.1074/jbc.M505055200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16272152-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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