Article
An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant.
Neuroscience letters - 25 Oct 2009
Zhong Huailing, Hansen Kasper B, Boyle Noel J, Han Kiho, Muske Galina, Huang Xinyan, Egebjerg Jan, Sánchez Connie
Abstract excerpt
The human serotonin transporter (hSERT) has primary and allosteric binding sites for escitalopram and R-citalopram. Previous studies have established that the interaction of these two compounds at a low affinity allosteric binding site of hSERT can affect the dissociation of [(3)H]escitalopram from hSERT. The allosteric binding site involves a series of residues in the 10th, 11th, and 12th trans-membrane domains...
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