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Article

High- and low-affinity binding of S-citalopram to the human serotonin transporter mutated at 20 putatively important amino acid positions.

Neuroscience letters - 5 Aug 2005

Plenge Per, Wiborg Ove

Abstract excerpt

The serotonin transporter (SERT) is responsible for terminating or modulating the action of serotonin released from the presynaptic neuron and is the major target for most antidepressants including the tricyclic antidepressants and the selective serotonin uptake inhibitors. Two binding sites for uptake inhibitors and serotonin (5-HT) have been found on SERT. At one site, uptake inhibitors bind with high-affinity...

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PMID: 15955412
DOI: 10.1016/j.neulet.2005.04.028

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